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Vaksin subunit seperti yang dicontohkan oleh vaksin hepatitis B rekombinan hanya mencakup epitop (bagian spesifik dari antigen yang antibodi atau sel-T mengenali dan mengikat) yang paling mudah merangsang sistem kekebalan tubuh.Jika itu adalah antigen virus, antigen akan terikat dengan protein MHC I dan disajikan oleh sel antigen-presenting ke sel